GHRH analogues
GHRH analogues groups 3 indexed compounds. Also written as growth hormone releasing factor analogues, GRF analogues, GHRH 1-29 analogues.
Definition
GHRH analogues are peptides modelled on growth hormone releasing hormone, which act at the GHRH receptor on the anterior pituitary. A 2005 Endocrinology paper reports that human growth hormone releasing factor 1-29 albumin bioconjugates activate the GRF receptor, and a 1985 Endocrinology paper examines the structural requirements for activation of rat anterior pituitary adenylate cyclase by growth hormone releasing factor.
[1, 2]Class-level mechanism as reported
The class acts upstream of growth hormone release at the GHRH receptor, which distinguishes it from the growth hormone secretagogues that act at the ghrelin receptor. The retrieved literature on this class is largely concerned with how modification extends duration of action: a 2006 Journal of Clinical Endocrinology and Metabolism paper reports prolonged stimulation of growth hormone and IGF-I secretion by CJC-1295.
[1, 3]Members
| Compound | Other names | Peptide | Reported half-life |
|---|---|---|---|
| Sermorelin | GRF 1-29, GHRH 1-29, geref | Yes | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
| Tesamorelin | TH9507, Egrifta | Yes | Withheld pending qualified review |
| CJC-1295 | DAC:GRF, CJC-1295 DAC, CJC-1295 with DAC | Yes | Withheld pending qualified review |
2 of 3 compounds in this class are withheld pending qualified review, so their reported values are not shown here and their pages are not published. They are listed because the class is incomplete without them.
Where this page sits
Research records for compounds in this class
Side-by-side pages within this class
- CJC-1295 and Sermorelin side by side
- CJC-1295 and Tesamorelin side by side
- Sermorelin and Tesamorelin side by side
All classes: class index. All compounds: compound index.
Sources
- Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology (2005). pmid:15817669
- Structural requirements for the activation of rat anterior pituitary adenylate cyclase by growth hormone-releasing factor (GRF): discovery of (N-Ac-Tyr1, D-Arg2)-GRF(1-29)-NH2 as a GRF antagonist on membranes. Endocrinology (1985). pmid:2994998
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab (2006). pmid:16352683
On each stated value was matched to the record cited for it. That is record matching, not an appraisal of the research. Compiled and checked by: Peptide Monographs editorial desk. No qualified clinical reviewer.