Thymalin

Thymalin is a peptide, indexed here under Short peptide bioregulators.

Identity

Measured identity values, each with the source that reports it
Field	Value
Classification	Peptide
Primary class	Short peptide bioregulators
CAS registry number	Unknown PubChem returned no compound record for this name on the retrieval date, so this field is not sourced.
PubChem CID	Unknown PubChem returned no compound record for this name on the retrieval date, so this field is not sourced.
UniProt accession	Unknown No UniProt query was run in v1.
Molecular formula	Unknown PubChem returned no compound record for this name on the retrieval date, so this field is not sourced.
Molecular weight	Unknown PubChem returned no compound record for this name on the retrieval date, so this field is not sourced.
Amino-acid sequence	Unknown Not reported by the PubChem property set retrieved for this record; no sequence database query was run in v1.
Reported half-life	Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated.

What the cited literature examines

Thymalin is a polypeptide extract of the thymus rather than a defined molecule, so its identity fields on this page are unsourced; a 2023 International Journal of Molecular Sciences paper examines the influence of the KE and EW dipeptides in its composition on gene expression and protein synthesis. A 2020 Bulletin of Experimental Biology and Medicine paper reports activation of differentiation of human haematopoietic stem cells, and a 2003 paper in the same journal reports thymalin in developing respiratory organs of the human fetus.

The older records are Russian experimental immunology: a 1987 paper on vitamin E and thymalin in experimental allergic encephalomyelitis, a 1987 Voprosy Onkologii paper on thymalin and epithalamin and the metastasis of irradiated experimental tumours, a 1991 Vestnik Oftalmologii paper on T-activin and thymalin in ophthalmic herpes, a 2004 paper on thyroxine and thymalin and thymocyte proliferation in thyroidectomised rats, and a 2018 Bulletin of Experimental Biology and Medicine paper on tumour and thymus under activation therapy. Two 2024 Polish-journal papers report mandibular bone regenerate histology, and a 2022 Advances in Gerontology paper reports blood clotting indicators in severe COVID-19 patients.

^{[2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12]}

Reported mechanism

A thymic polypeptide extract whose constituent KE and EW dipeptides are reported in the retrieved 2023 record to act on gene expression and protein synthesis; immune cell differentiation endpoints are reported elsewhere in the set.

^{[2, 3]}

Stated in the titles of the cited 2023 International Journal of Molecular Sciences and 2020 Bulletin of Experimental Biology and Medicine papers.

Targets named in the cited records: gene expression, haematopoietic stem cell differentiation.

FDA application register

A query of the FDA Drugs@FDA application register on 2026-10-09 returned no application records for this compound name. This compound is not approved by the FDA for human use.^[1]

Scope statement: this records the result of a single automated query against the openFDA drugsfda endpoint on the stated date. It is not legal advice and is not a jurisdiction-by-jurisdiction legality assessment.

Retrieved 2026-10-09.

Amounts reported in the cited literature

Unknown. No retrieved record in this dataset states an amount, so none is shown. Where an amount is recorded it is what a named study reported administering in its own stated model, in the past tense, and is not a protocol.

No study-reported dose was taken from a source read in v1. Literature-reported values are only recorded where the retrieved citation metadata states the figure.

Adverse effects reported in the cited literature

Unknown. No retrieved record in this dataset reports an adverse effect for this compound, so no row is shown. Absence of a row records the absence of a retrieved report, nothing more.

No adverse-effect row was taken from a source read in v1. Rows are only recorded with the study model named and the reporting citation attached.

Other names

Thymalin appears under these other names in the cited records or in common usage. Each one resolves to this page rather than to a separate page of its own.

thymus polypeptide extract
Thymalinum

Where this page sits

Research records

Cited research records for Thymalin, each with its identifier, the publication type it is indexed as, and the study model stated by its assigned subject headings.

Compounds indexed next to it

Thymosin alpha 1 — Endocrine and immune signalling peptides
Thymulin — Endocrine and immune signalling peptides

Class page: Short peptide bioregulators. Full index: all indexed compounds.

Questions this page answers

What does the cited literature examine for Thymalin?

Which class is Thymalin indexed under?

Thymalin is indexed under Short peptide bioregulators. This class groups the short synthetic peptides and tissue polypeptide extracts developed by the St Petersburg bioregulator programme, which research-peptide catalogues sell as a family.

What does the FDA application register show for Thymalin?

A query of the FDA Drugs@FDA application register on 2026-10-09 returned no application records for this compound name. This compound is not approved by the FDA for human use.

Sources

Drugs@FDA application register query for this compound, no application records returned. U.S. Food and Drug Administration, openFDA drugsfda endpoint (2026). fda:thymalin
The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19. International journal of molecular sciences (2023). pmid:37686182
Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells. Bulletin of experimental biology and medicine (2020). pmid:33237528
Thymalin in developing respiratory organs of human fetus. Bulletin of experimental biology and medicine (2003). pmid:12937685
[Effect of vitamin E and thymalin on the development of experimental allergic encephalomyelitis]. Biulleten' eksperimental'noi biologii i meditsiny (1987). pmid:3663910
[Effect of thymalin and epithalamin on the metastasis of experimental tumors irradiated with pulsed laser radiation]. Voprosy onkologii (1987). pmid:3811311
[Use of T-activin and thymalin in the treatment of ophthalmic herpes]. Vestnik oftalmologii (1991). pmid:1763455
[Effect of thyroxin and thymalin on proliferation and apoptosis of thymocytes in rats after thyroidectomy]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) (2004). pmid:15320428
Effect of Thymalin on the Tumor and Thymus under Conditions of Activation Therapy In Vivo. Bulletin of experimental biology and medicine (2018). pmid:29797130
Expression features of T-lymphocytes, B-lymphocytes and macrophages in the post-traumatic regenerate of the mandible rats under conditions of filling a bone defect with hydroxyapatite-containing osteotropic material and thymalin injecting the surrounding soft tissues. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (2024). pmid:38642352
Reparative osteogenesis in mandible in cases of filling a bone defect with hydroxyapatite-containing osteotropic material and injecting the surrounding soft tissues with thymalin: experimental and morphological study. Wiadomosci lekarskie (Warsaw, Poland : 1960) (2024). pmid:38431810
[Morphological compound and indicators of the blood clotting system in severe COVID-19 patients of middle aged and elderly during treatment of Tocilizumab and Thymalin.]. Advances in gerontology = Uspekhi gerontologii (2022). pmid:36169363

On 2026-10-09 each stated value was matched to the record cited for it. That is record matching, not an appraisal of the research. Compiled and checked by: Peptide Monographs editorial desk. No qualified clinical reviewer.